*Indicates corresponding authorships
2022
BIOLOGICALLY ACTIVE PEPTIDES FROM VENOMS: APPLICATIONS IN ANTIBIOTIC RESISTANCE, CANCER, AND BEYOND
Lucía Ageitos, Marcelo Der Torossian Torres, and Cesar de la Fuente-Nunez*
International Journal of Molecular Sciences, 23, 23, 15437, 2022, December 6
BACTERIAL RESISTANCE TO ANTIBACTERIAL AGENTS: MECHANISMS, CONTROL STRATEGIES, AND IMPLICATIONS FOR GLOBAL HEALTH
Ting Li, Zhenlong Wang, Jianhua Guo*, Cesar de la Fuente-Nunez*, Jinquan Wang, Bing Han, Hui Tao, Jie Liu, and Xiumin Wang*
Science of The Total Environment, 2022, November 23
MOLECULAR DE-EXTINCTION OF ANCIENT ANTIMICROBIAL PEPTIDES ENABLED BY MACHINE LEARNING
Jacqueline R. M. A. Maasch, Marcelo D. T. Torres, Marcelo C. R. Melo, Cesar de la Fuente-Nunez*
bioRxiv, 2022, November 15
MOLECULAR TOOLS FOR PROBING THE MICROBIOME
Marcelo D. T. Torres, Cesar de la Fuente-Nunez
Current Opinion in Structural Biology, 2022, August 16
AN N-CAPPING ASPARAGINE-LYSINE-PROLINE (NKP) MOTIF CONTRIBUTES TO A HYBRID FLEXIBLE/STABLE MULTIFUNCTIONAL PEPTIDE SCAFFOLD
Marlon H. Cardoso, Lai Y. Chan, Elizabete S. Cândido, Danieli F. Buccini, Samilla B. Rezende, Marcelo D. T. Torres, Karen G. N. Oshiro, Ítala C. Silva, Sónia Gonçalves, Timothy K. Lu, Nuno C. Santos, Cesar de la Fuente-Nunez, David J. Craik and Octávio L. Franco
Chemical Science, 2022, August 4
DEBULKING DIFFERENT CORONA (SARS-COV-2, DELTA, OMICRON, OC43) AND INFLUENZA (H1N1, H3N2) VIRUS STRAINS BY PLANT VIRAL TRAP PROTEINS IN CHEWING GUMS TO DECREASE INFECTION AND TRANSMISSION
Henry Daniell, Smruti K. Nair, Hancheng Guan, Yuwei Guo, Rachel J. Kulchar, Marcelo D. T. Torres, Md Shahed-Al-Mahmud, Geetanjali Wakade, Yo-Min Liu, Andrew Marques, Jevon Graham-Wooten, Wan Zhou, Ping Wang, Sudheer K. Molugu, William R. de Araujo, Cesar de la Fuente-Nunez, Che Ma, William R. Short ... Mark S. Wolff
Biomaterials, 2022, July 18
IMPACT OF NATURAL SELECTION ON GLOBAL PATTERNS OF GENETIC VARIATION AND ASSOCIATION WITH CLINICAL PHENOTYPES AT GENES INVOLVED IN SARS-COV-2 INFECTION
Chao Zhang, Anurag Verma, Yuanqing Feng, Marcelo C. R. Melo, Michael McQuillan, Matthew Hansen, Anastasia Lucas, Joseph Park, Alessia Ranciaro, Simon Thompson, Meagan A. Rubel, Michael C. Campbell, William Beggs, Jibril Hirbo, Sununguko Wata Mpoloka, Gaonyadiwe George Mokone, Regeneron Genetic Center, Thomas Nyambo, Dawit Wolde Meskel, Gurja Belay, Charles Fokunang, Alfred K. Njamnshi, Sabah A. Omar, Scott M. Williams, Daniel J. Rader, Marylyn D. Ritchie, Cesar de la Fuente-Nunez, Giorgio Sirugo, and Sarah A. Tishkoff
PNAS, 2022, May 17
ANTIBIOTIC DISCOVERY WITH MACHINE LEARNING
Cesar de la Fuente-Nunez*
Nature Biotechnology, 2022, May 6
AUTONOMOUS TREATMENT OF BACTERIAL INFECTIONS IN VIVO USING ANTIMICROBIAL MICRO- AND NANOMOTORS
Xavier Arqué, Marcelo D. T. Torres, Tania Patiño, Andreia Boaro, Samuel Sánchez*, Cesar de la Fuente-Nunez*
ACS Nano, 2022, April 29
DEEP GENERATIVE MODELS FOR PEPTIDE DESIGN
Fangping Wan, Daphne Kontogiorgos-Heintz, Cesar de la Fuente-Nunez*
Digital Discovery, 2022, March 31
DETECTION OF SARS-COV-2 WITH RAPID: A PROSPECTIVE COHORT STUDY
Marcelo D.T. Torres, Lucas F. de Lima, André L. Ferreira, William R. de Araujo, Paul Callahan, Antonio Dávila, Benjamin S. Abella, Cesar de la Fuente-Nunez*
iScience, 2022, March 11
MACHINE LEARNING FOR DRUG DISCOVERY
Marcelo C.R. Melo, Jacqueline R.M.A. Maasch, Cesar de la Fuente-Nunez*
American Chemical Society, 2022, March 11
SYNTHETIC ANTIBIOTIC DERIVED FROM SEQUENCES ENCRYPTED IN A PROTEIN FROM HUMAN PLASMA
Angela Cesaro, Marcelo Der Torossian Torres, Rosa Gaglione, Eliana Dell'Olmo, Rocco Di Girolamo, Andrea Bosso, Elio Pizzo, Henk P. Haagsman, Edwin J. A. Veldhuizen, Cesar de la Fuente-Nunez*, and Angela Arciello
ACS Nano, 2022, Feb 3
2021
MINING FOR ENCRYPTED PEPTIDE ANTIBIOTICS IN THE HUMAN PROTEOME
Marcelo Der Torossian Torres, Marcelo C. R. Melo, Orlando Crescenzi, Eugenio Notomista, Cesar de la Fuente-Nunez*
Nature Biomedical Engineering, 2021, Nov 4
LOW-COST OPTODIAGNOSTIC FOR MINUTE-TIME SCALE DETECTION OF SARS-COV-2
Andre Lopes Ferreira, Lucas Felipe de Lima, Marcelo Der Torossian Torres, William Reis de Araujo*, Cesar de la Fuente-Nunez*
ACS Nano, 2021, Oct 20
PROBIOTIC ENGINEERING STRATEGIES FOR THE HETEROLOGOUS PRODUCTION OF ANTIMICROBIAL PEPTIDES
Adriana Mejia-Pitta, Esther Broset, Cesar de la Fuente-Nunez*
Advanced Drug Delivery Reviews, 2021, 176:113863
ACCELERATING ANTIBIOTIC DISCOVERY THROUGH ARTIFICIAL INTELLIGENCE
Marcelo C. R. Melo, Jacqueline R. M. A. Maasch, Cesar de la Fuente-Nunez*
Communications Biology, 2021, 4(1):1050
MINUTE-SCALE DETECTION OF SARS-COV-2 USING A LOW-COST BIOSENSOR COMPOSED OF PENCIL GRAPHITE ELECTRODES
Lucas F. de Lima, André L. Ferreira, Marcelo D. T. Torres, William R. de Araujo, Cesar de la Fuente-Nunez*
Proceedings of the National Academy of Sciences, 2021, 118, 30, e2106724118
SYNTHETIC PEPTIDE DERIVED FROM SCORPION VENOM DISPLAYS MINIMAL TOXICITY AND ANTI-INFECTIVE ACTIVITY IN AN ANIMAL MODEL
Cyntia Silva Oliveira, Marcelo D. T. Torres, Cibele Nicolaski Pedron, Viviane Brito Andrade, Pedro Ismael Silva Jr., Fernanda Dias Silva, Cesar de la Fuente-Nunez*, Vani Xavier Oliveira Jr.
ACS Infectious Diseases, 2021, 7, 9, 2736-2745
LOW-COST BIOSENSOR FOR RAPID DETECTION OF SARS-COV-2 AT POINT-OF-CARE
Marcelo D. T. Torres, William R. de Araujo, Lucas F. de Lima, André L. Ferreira, Cesar de la Fuente-Nunez*
Matter, 2021, 4, 7, 2403-2416
ANTIMICROBIAL SUSCEPTIBILITY TESTING OF ANTIMICROBIAL PEPTIDES REQUIRES NEW AND STANDARDIZED TESTING STRUCTURES
Marita Meurer, Deborah A. O'Neil, Emma Lovie, Laura Simpson, Marcelo D. T. Torres, Cesar de la Fuente-Nunez, Alfredo M. Angeles-Boza, Christin Kleinsorgen, Derry K. Mercer, Maren von Kockritz-Blickwede
ACS Infectious Diseases, 2021, 7, 8, 2205-2208
HYDROGEL-BASED BIOCONTAINMENT OF BACTERIA FOR CONTINUOUS SENSING AND COMPUTATION
Tzu-Chieh Tang, Eleonore Tham, Xinyue Liu, Kevin Yehl, Alexis J. Rovner, Hyunwoo Yuk, Cesar de la Fuente-Nunez, Farren J. Isaacs, Xuanhe Zhao, Timothy K. Lu
Nature Chemical Biology, 2021, 17, 724-731
MOLECULAR DYNAMICS FOR ANTIMICROBIAL PEPTIDE DISCOVERY
Nicholas Palmer, Jacqueline R. M. A. Massch, Marcelo D. T. Torres, Cesar de la Fuente-Nunez*
Infection and Immunity, 2021, 89:e00703-20
SYNTHETIC BIOLOGY AND COMPUTER-BASED FRAMEWORKS FOR ANTIMICROBIAL PEPTIDE DISCOVERY
Marcelo D. T. Torres, Jicong Cao, Octavio L. Franco, Timothy K. Lu, Cesar de la Fuente-Nunez*
ACS Nano, 2021, 15, 2, 2143-2164
ANTIBIOFILM PEPTIDES: RELEVANT PRECLINICAL ANIMAL INFECTION MODELS AND TRANSLATIONAL POTENTIAL
Gislaine G. O. Silveira, Marcelo D. T. Torres, Camila F. A. Ribeiro, Beatriz T. Meneguetti, Cristiano M. E. Carvalho, Cesar de la Fuente-Nunez, Octavio L. Franco, Marlon H. Cardoso
ACS Pharmacology and Translational Science, 2021, 4, 1, 55-73
NET CHARGE TUNING MODULATES THE ANTIPLASMODIAL AND ANTICANCER PROPERTIES OF PEPTIDES DERIVED FROM SCORPION VENOM
Cibele Nicolaski Pedron, Adriana Farias Silva, Marcelo Der Torossian Torres, Cynthia Silva de Oliveira, Gislaine Patricia Andrade, Giselle Cerchiaro, Maria Aparecida Silva Pinhal, Cesar de la Fuente-Nunez*, and Vani Xavier Oliveira Junior*
Journal of Peptide Science, 2021, 27:e3296
COATABLE AND RESISTANCE-PROOF IONIC LIQUID FOR PATHOGEN ERADICATION
Marcelo D. T. Torres, Sahag Voskian, Paul Brown, Andong Liu, Timothy K. Lu, T. Alan Hatton, and Cesar de la Fuente-Nunez*
ACS Nano, 2021, 15, 1, 966-978
2020
SYNTHETIC HOST DEFENSE PEPTIDES INHIBIT VENEZUELAN EQUINE ENCEPHALITIS VIRUS REPLICATION AND THE ASSOCIATED INFLAMMATORY RESPONSE
Aslaa Ahmed, Allison Bakovic, Kenneth Risner, Stephanie Kortchak, Marcelo Der Torossian Torres, Cesar de la Fuente-Nunez, Timothy Lu, Nishank Bhalla, Aarthi Narayanan
Scientific Reports, 2020, 10:21491
LIGHT-EMITTING PROBES FOR LABELING PEPTIDES
Andreia Boaro, Lucia Ageitos, Marcelo Der Torossian Torres, Fernando H. Bartoloni, Cesar de la Fuente-Nunez*
Cell Reports Physical Science, 2020
STRATEGIES FOR ANTIMICROBIAL PEPTIDE COATINGS ON MEDICAL DEVICES: A REVIEW AND REGULATORY SCIENCE PERSPECTIVE
Mehdi Kazemzadeh-Narbat, Hao Cheng, Rosa Chabok, Mario Moises Alvarez, Cesar de la Fuente-Nunez, K. Scott Phillips, Ali Khademhosseini
Critical Reviews in Biotechnology, 2020, 117, 41, 1, 94-120
REPURPOSING A PEPTIDE TOXIN FROM WASP VENOM INTO ANTIINFECTIVES WITH DUAL ANTIMICROBIAL AND IMMUNOMODULATORY PROPERTIES
Osmar N. Silva, Marcelo Der Torossian Torres, Jicong Cao, Eliane S. F. Alves, Leticia V. Rodrigues, Jarbas M. Resende, Luciano M. Liao, William F. Porto, Isabel C. M. Fensterseifer, Timothy K. Lu, Octavio L. Franco, Cesar de la Fuente-Nunez*
PNAS, 2020, 117, 43, 26936-26945
GENERALIZED CORRELATION-BASED DYNAMICAL NETWORK ANALYSIS: A NEW HIGH-PERFORMANCE APPROACH FOR IDENTIFYING ALLOSTERIC COMMUNICATIONS IN MOLECULAR DYNAMICS TRAJECTORIES
Marcelo C. R. Melo, Rafael C. Bernardi, Cesar de la Fuente-Nunez, Zaida Luthey-Schulten
The Journal of Chemical Physics, 2020, 153, 13, 134104
PHYSICAL METHODS FOR CONTROLLING BACTERIAL COLONIZATION ON POLYMERIC SURFACES
Coro Echeverria, Marcelo Der Torossian Torres, Marta Fernandez-Garcia, Cesar de la Fuente-Nunez*, Alexandra Munoz-Bonilla
Biotechnology Advances, 2020, 43, 107586
THE VALUE OF ANTIMICROBIAL PEPTIDES IN THE AGE OF RESISTANCE
Maria Magana, Muthuirulan Pushpanatan, Ana L. Santos, Leon Leanse, Michael Fernandez, Anastasios Ionnidis, Marc A. Giulianotti, Yiorgos Apidianakis, Steven Bradfute, Andrew L. Ferguson, Artem Cherkasov, Mohamed N. Seleem, Clemencia Pinilla, Cesar de la Fuente-Nunez, Themis Lazaridis, Tianhong Dai, Richard A Houghten, Robert E. W. Hancock, Geroge P. Tegos
The Lancet Infectious Diseases, 2020
ANTIMICROBIAL SUSCEPTIBILITY TESTING OF ANTIMICROBIAL PEPTIDES TO BETTER PREDICT EFFICACY
Derry K. Mercer, Marcelo Der Torossian Torres, Searle S. Duay, Emma Lovie, Laura Simpson, Maren von Kockritz-Blickwede, Cesar de la Fuente-Nunez, Deborah A. O'Neil, Alfredo M. Angeles-Boza
Frontiers in Cellular and Infection Microbiology, 2020, 10:326
THE WASP VENOM ANTIMICROBIAL PEPTIDE POLYBIA-CP AND ITS SYNTHETIC DERIVATIVES DISPLAY ANTIPLASMODIAL AND ANTICANCER PROPERTIES
Marcelo Der Torossian Torres, Adriana F. Silva, Gislaine P. Andrade, Cibele N. Pedron, Giselle Cerchiaro, Anderson O. Ribeiro, Vani X. Oliveira Jr, Cesar de la Fuente-Nunez*
Bioengineering & Translational Medicine, 2020
HOST DEFENCE CRYPTIDES FROM HUMAN APOLIPOPROTEINS: APPLICATIONS IN MEDICINAL CHEMISTRY
Rosa Gaglione, Elio Pizzo, Eugenio Notomista, Cesar de la Fuente-Nunez, Angela Arciello
Current Topics in Medicinal Chemistry, 2020, 20, 14, 1324-1337
UNDERSTANDING AND MODELLING THE INTERACTIONS OF PEPTIDES WITH MEMBRANES: FROM PARTITIONING TO SELF-ASSEMBLY
Charles H. Chen, Marcelo C. R. Melo, Nils Berglund, Ayesha Khan, Cesar de la Fuente-Nunez*, Jakob P. Ulmschneider, Martin B Ulmschneider
Current Opinion in Structural Biology, 2020, 61, 160-166
2019
REPROGRAMMING BIOLOGICAL PEPTIDES TO COMBAT INFECTIOUS DISEASES
Marcelo Der Torossian Torres and Cesar de la Fuente-Nunez*
Chemical Communications, 2019
EMERGING FRONTIERS IN MICROBIOME ENGINEERING
María Eugenia Inda, Esther Broset, Timothy K. Lu, Cesar de la Fuente-Nunez*
Trends in Immunology, 2019
ENGINEERING PHAGE HOST-RANGE AND SUPPRESSING BACTERIAL RESISTANCE THROUGH PHAGE TAIL FIBER MUTAGENESIS
Kevin Yehl, Sébastien Lemire, Andrew C. Yang, Hiroki Ando, Mark Mimee, Marcelo Der Torossian Torres, Cesar de la Fuente-Nunez, and Timothy K. Lu
Cell, 2019, 179, 2, 459-469
ANTIMICROBIAL AND ANTIBIOFILM ACTIVITIES OF HELICAL ANTIMICROBIAL PEPTIDE SEQUENCES INCORPORATING METAL-BINDING MOTIFS
Caleb M. Agbale, Justice K. Sarfo, Isaac K. Galyuon, Samuel A. Juliano, Gislaine G. O. Silva, Danieli F. Buccini, Marlon H. Cardoso, Marcelo Der Torossian Torres, Alfredo M. Angeles-Boza, Cesar de la Fuente-Nunez*, and Octavio L. Franco
Biochemistry, 2019, 58, 36, 3802-3812
COMPUTER-AIDED DESIGN OF MASTOPARAN-LIKE PEPTIDES ENABLES THE GENERATIO OF NONTOXIC VARIANTS WITH EXTENDED ANTIBACTERIAL PROPERTIES
Karen G. N. Oshiro, Elizabete S. Candido, Lai Y. Chan, Marcelo Der Torossian Torres, Bruna E. D. Monges, Silvia G. Rodrigues, William F. Porto, Suzana M. Ribeiro, Sonia T. Henriques, Timothy K. Lu, Cesar de la Fuente-Nunez, David J. Craik, Octavio L. Franco, and Marlon H. Cardoso
Jounal of Medicinal Chemistry, 2019, 62, 17, 8140-8151
TOWARD COMPUTER-MADE ARTIFICIAL ANTIBIOTICS
Marcelo Der Torossian Torres and Cesar de la Fuente-Nunez*
Current Opinion in Microbiology, 2019, 51, 30-38
HUMAN CATHELICIDIN PEPTIDE LL-37 AS A THERAPEUTIC ANTIVIRAL TARGETING VENEZUELAN EQUINE ENCEPHALITIS VIRUS INFECTIONS
Aslaa Ahmed, Gavriella Siman-Tov, Forrest Keck, Stephanie Kortchak, Allison Bakovic, Kenneth Risner, Timothy K. Lu, Nishank Bhalla, Cesar de la Fuente-Nunez*, and Aarthi Narayanan
Antiviral Research, 2019, 164, 61-69
SHORT CATIONIC PEPTIDE DERIVED FROM ARCHAEA WITH DUAL ANTIBACTERIAL PROPERTIES AND ANTI-INFECTIVE POTENTIAL
Elizabete S. Candido, Marlon H. Cardoso, Lai Y. Chan, Marcelo Der Torossian Torres, Karen G. N. Oshiro, William F. Porto, Suzana M. Ribeiro, Evan F. Haney, Robert E. W. Hancock, Timothy K. Lu, Cesar de la Fuente-Nunez*, David J. Craik, and Octavio L. Franco
ACS Infectious Diseases, 2019
SELECTIVE ANTIBACTERIAL ACTIVITY OF THE CATIONIC PEPTIDES PaDBS1R6 AGAINST GRAM-NEGATIVE BACTERIA
Isabel C. M. Fensterseifer, Mario R. Felicio, Eliane S. F. Alves, Marlon H. Cardoso, Marcelo Der Torossian Torres, Carolina O. Matos, Osmar N. Silva, Timothy K. Lu, Mauricio V. Freire, Natan C. Neves, Sonia Gonçalves, Luciano M. Liao, Nuno C. Santos, William F. Porto, Cesar de la Fuente-Nunez*, Octavio L. Franco
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2019, 1861 (7), 1375-1387
PEPTIDE DESIGN PRINCIPLES FOR ANTIMICROBIAL APPLICATIONS
Marcelo Der Torossian Torres, Shanmugapriya Sothiselvam, Timothy K. Lu, and Cesar de la Fuente-Nunez*
Journal of Molecular Biology, 2019
2018
STRUCTURE-FUNCTION-GUIDED EXPLORATION OF THE ANTIMICROBIAL PEPTIDE POLYBIA-CP IDENTIFIES ACTIVITY DETERMINANTS AND GENERATES SYNTHETIC THERAPEUTICS CANDIDATES
Marcelo Der Torossian Torres, Cibele N. Pedron, Yasutomi Higashikuni, Robin M. Kramer, Marlon H. Cardoso, Karen G. N. Oshiro, Octávio L. Franco, Pedro I. Silva Junior, Fernanda D. Silva, Vani X. Oliveira Junior, Timothy K. Lu, Cesar de la Fuente-Nunez*
Nature Communications Biology, 2018, 1, 221 (Editor's pick)
IDENTIFICATION OF NOVEL CRYPTIC MULTIFUNCTIONAL ANTIMICROBIAL PEPTIDES FROM THE HUMAN STOMACH ENABLED BY A COMPUTATIONAL–EXPERIMENTAL PLATFORM
Katia Pane, Valeria Cafaro, Angela Avitable, Marcelo Der Torossian Torres, Adriana Vollaro, Eliana De Gregorio, Maria Rosaria Catania, Antimo Di Maro, Andrea Bosso, Giovanni Gallo, Anna Zanfardino, Mario Varcamonti, Elio Pizzo, Alberto Di Donato, Thimothy K. Lu, Cesar de la Fuente-Nunez*, and Eugenio Notomista
ACS Synthetic Biology, 2018, 7 (9), 2105–2115