Introduction Artificial intelligence algorithms have now been combined with traditional laboratory methods to uncover promising drug leads against human enterovirus 71 (EV71), the pathogen behind most cases of hand, foot and mouth disease. The study published in Cell Reports Physical Science showed that reliable antiviral predictions can be made even when only a modest amount […]

Introduction In a move that underscores the urgent race to outpace antibiotic-resistant bacteria, researchers from the Machine Biology Group has turned to an unusual source for innovative treatments: frogs. In the paper published in Trends in Biotechnology (Cell Press), scientists detail how synthetic peptides—modeled after natural compounds found in the frog species Odorrana andersonii—show promise […]

Introduction In a new study, researchers from the Machine Biology Group have unveiled a novel class of antimicrobial agents dubbed encrypted peptides. his research—published in Trends in Biotechnology by Cell Press—challenges long-standing ideas about the immune system and opens exciting possibilities for new treatments. A Shift in Understanding Immunity Traditionally, we’ve viewed the immune system […]

Introduction In response to the alarming rise of drug-resistant bacteria, which has far outpaced the development of conventional antibiotics, our latest research published in Cell has identified a promising new avenue for antibiotic discovery within the human microbiome. As global health faces a severe threat from antibiotic resistance, our team in collaboration with Ami S. […]

Introduction Antimicrobial resistance (AMR) is one of the greatest threats facing humanity today, making the need for new antibiotics more critical than ever. Traditional approaches to antibiotic discovery are painstakingly slow, often taking years to identify preclinical candidates. In a groundbreaking study published in Nature Biomedical Engineering, our team introduces APEX, a new AI model […]

Introduction Antimicrobial resistance is one of the greatest threats facing humanity and novel antibiotics are urgently needed. In a recent study published in Cell, our team, along with fantastic collaborators, leveraged computational techniques to accelerate the search for new antimicrobial compounds, specifically focusing on antimicrobial peptides (AMPs). By employing advanced genome mining methods, we identified […]