*Indicates corresponding authorships

2021

MOLECULAR DYNAMICS FOR ANTIMICROBIAL PEPTIDE DISCOVERY
Nicholas Palmer, Jacqueline R. M. A. Massch, Marcelo D. T. Torres, Cesar de la Fuente-Nunez*
Infection and Immunity, 2021, 89:e00703-20

 

SYNTHETIC BIOLOGY AND COMPUTER-BASED FRAMEWORKS FOR ANTIMICROBIAL PEPTIDE DISCOVERY
Marcelo D. T. Torres, Jicong Cao, Octavio L. Franco, Timothy K. Lu, Cesar de la Fuente-Nunez*
ACS Nano, 2021, 15, 2, 2143-2164 

 

ANTIBIOFILM PEPTIDES: RELEVANT PRECLINICAL ANIMAL INFECTION MODELS AND TRANSLATIONAL POTENTIAL
Gislaine G. O. Silveira, Marcelo D. T. Torres, Camila F. A. Ribeiro, Beatriz T. Meneguetti, Cristiano M. E. Carvalho, Cesar de la Fuente-Nunez, Octavio L. Franco, Marlon H. Cardoso
ACS Pharmacology and Translational Science, 2021, 4, 1, 55-73 

 

NET CHARGE TUNING MODULATES THE ANTIPLASMODIAL AND ANTICANCER PROPERTIES OF PEPTIDES DERIVED FROM SCORPION VENOM
 Cibele Nicolaski Pedron, Adriana Farias Silva, Marcelo Der Torossian Torres, Cynthia Silva de Oliveira, Gislaine Patricia Andrade, Giselle Cerchiaro, Maria Aparecida Silva Pinhal, Cesar de la Fuente-Nunez*, and Vani Xavier Oliveira Junior*
Journal of Peptide Science, 2021, 27:e3296 

 

COATABLE AND RESISTANCE-PROOF IONIC LIQUID FOR PATHOGEN ERADICATION
 Marcelo D. T. Torres, Sahag Voskian, Paul Brown, Andong Liu, Timothy K. Lu, T. Alan Hatton, and Cesar de la Fuente-Nunez*
ACS Nano, 2021, 15, 1, 966-978 

 

2020

LIGHT-EMITTING PROBES FOR LABELING PEPTIDES
Andreia Boaro, Lucia Ageitos, Marcelo Der Torossian Torres, Fernando H. Bartoloni, Cesar de la Fuente-Nunez*
Cell Reports Physical Science, 2020 

 

REPURPOSING A PEPTIDE TOXIN FROM WASP VENOM INTO ANTIINFECTIVES WITH DUAL ANTIMICROBIAL AND IMMUNOMODULATORY PROPERTIES
Osmar N. Silva, Marcelo Der Torossian Torres, Jicong Cao, Eliane S. F. Alves, Leticia V. Rodrigues, Jarbas M. Resende, Luciano M. Liao, William F. Porto, Isabel C. M. Fensterseifer, Timothy K. Lu, Octavio L. Franco, Cesar de la Fuente-Nunez*
PNAS, 2020, 117, 43, 26936-26945 

 

PHYSICAL METHODS FOR CONTROLLING BACTERIAL COLONIZATION ON POLYMERIC SURFACES
Coro Echeverria, Marcelo Der Torossian Torres, Marta Fernandez-Garcia, Cesar de la Fuente-Nunez*, Alexandra Munoz-Bonilla
Biotechnology Advances, 2020, 43, 107586 

 

THE VALUE OF ANTIMICROBIAL PEPTIDES IN THE AGE OF RESISTANCE
Maria Magana, Muthuirulan Pushpanatan, Ana L. Santos, Leon Leanse, Michael Fernandez, Anastasios Ionnidis, Marc A. Giulianotti, Yiorgos Apidianakis, Steven Bradfute, Andrew L. Ferguson, Artem Cherkasov, Mohamed N. Seleem, Clemencia Pinilla, Cesar de la Fuente-Nunez, Themis Lazaridis, Tianhong Dai, Richard A Houghten, Robert E. W. Hancock, Geroge P. Tegos
The Lancet Infectious Diseases, 2020 

 

ANTIMICROBIAL SUSCEPTIBILITY TESTING OF ANTIMICROBIAL PEPTIDES TO BETTER PREDICT EFFICACY
Derry K. Mercer, Marcelo Der Torossian Torres, Searle S. Duay, Emma Lovie, Laura Simpson, Maren von Kockritz-Blickwede, Cesar de la Fuente-Nunez, Deborah A. O'Neil, Alfredo M. Angeles-Boza
Frontiers in Cellular and Infection Microbiology, 2020, 10:326 

 

THE WASP VENOM ANTIMICROBIAL PEPTIDE POLYBIA-CP AND ITS SYNTHETIC DERIVATIVES DISPLAY ANTIPLASMODIAL AND ANTICANCER PROPERTIES
Marcelo Der Torossian Torres, Adriana F. Silva, Gislaine P. Andrade, Cibele N. Pedron, Giselle Cerchiaro, Anderson O. Ribeiro, Vani X. Oliveira Jr, Cesar de la Fuente-Nunez*
Bioengineering & Translational Medicine, 2020 

 

HOST DEFENCE CRYPTIDES FROM HUMAN APOLIPOPROTEINS: APPLICATIONS IN MEDICINAL CHEMISTRY
Rosa Gaglione, Elio Pizzo, Eugenio Notomista, Cesar de la Fuente-Nunez, Angela Arciello
Current Topics in Medicinal Chemistry, 2020, 20, 14, 1324-1337 

 

UNDERSTANDING AND MODELLING THE INTERACTIONS OF PEPTIDES WITH MEMBRANES: FROM PARTITIONING TO SELF-ASSEMBLY
Charles H. Chen, Marcelo C. R. Melo, Nils Berglund, Ayesha Khan, Cesar de la Fuente-Nunez*, Jakob P. Ulmschneider, Martin B Ulmschneider
Current Opinion in Structural Biology, 2020, 61, 160-166 

 

2019

REPROGRAMMING BIOLOGICAL PEPTIDES TO COMBAT INFECTIOUS DISEASES
Marcelo Der Torossian Torres and Cesar de la Fuente-Nunez*
Chemical Communications, 2019 

 

EMERGING FRONTIERS IN MICROBIOME ENGINEERING
María Eugenia Inda, Esther Broset, Timothy K. Lu, Cesar de la Fuente-Nunez*
Trends in Immunology, 2019 

 

ENGINEERING PHAGE HOST-RANGE AND SUPPRESSING BACTERIAL RESISTANCE THROUGH PHAGE TAIL FIBER MUTAGENESIS
Kevin Yehl, Sébastien Lemire, Andrew C. Yang, Hiroki Ando, Mark Mimee, Marcelo Der Torossian Torres, Cesar de la Fuente-Nunez, and Timothy K. Lu
Cell, 2019, 179, 2, 459-469

 

ANTIMICROBIAL AND ANTIBIOFILM ACTIVITIES OF HELICAL ANTIMICROBIAL PEPTIDE SEQUENCES INCORPORATING METAL-BINDING MOTIFS
Caleb M. Agbale, Justice K. Sarfo, Isaac K. Galyuon, Samuel A. Juliano, Gislaine G. O. Silva, Danieli F. Buccini, Marlon H. Cardoso, Marcelo Der Torossian Torres, Alfredo M. Angeles-Boza, Cesar de la Fuente-Nunez*, and Octavio L. Franco
Biochemistry, 2019, 58, 36, 3802-3812

 

COMPUTER-AIDED DESIGN OF MASTOPARAN-LIKE PEPTIDES ENABLES THE GENERATIO OF NONTOXIC VARIANTS WITH EXTENDED ANTIBACTERIAL PROPERTIES
Karen G. N. Oshiro, Elizabete S. Candido, Lai Y. Chan, Marcelo Der Torossian Torres, Bruna E. D. Monges, Silvia G. Rodrigues, William F. Porto, Suzana M. Ribeiro, Sonia T. Henriques, Timothy K. Lu, Cesar de la Fuente-Nunez, David J. Craik, Octavio L. Franco, and Marlon H. Cardoso
Jounal of Medicinal Chemistry, 2019, 62, 17, 8140-8151

 

TOWARD AUTONOMOUS ANTIBIOTIC DISCOVERY
Cesar de la Fuente-Nunez*
mSystems, 2019, 4, 3, e00151-19

 

TOWARD COMPUTER-MADE ARTIFICIAL ANTIBIOTICS
Marcelo Der Torossian Torres and Cesar de la Fuente-Nunez*
Current Opinion in Microbiology, 2019, 51, 30-38

 

HUMAN CATHELICIDIN PEPTIDE LL-37 AS A THERAPEUTIC ANTIVIRAL TARGETING VENEZUELAN EQUINE ENCEPHALITIS VIRUS INFECTIONS
Aslaa Ahmed, Gavriella Siman-Tov, Forrest Keck, Stephanie Kortchak, Allison Bakovic, Kenneth Risner, Timothy K. Lu, Nishank Bhalla, Cesar de la Fuente-Nunez*, and Aarthi Narayanan
Antiviral Research, 2019, 164, 61-69

 

SHORT CATIONIC PEPTIDE DERIVED FROM ARCHAEA WITH DUAL ANTIBACTERIAL PROPERTIES AND ANTI-INFECTIVE POTENTIAL
Elizabete S. Candido, Marlon H. Cardoso, Lai Y. Chan, Marcelo Der Torossian Torres, Karen G. N. Oshiro, William F. Porto, Suzana M. Ribeiro, Evan F. Haney, Robert E. W. Hancock, Timothy K. Lu, Cesar de la Fuente-Nunez*, David J. Craik, and Octavio L. Franco
ACS Infectious Diseases, 2019

 

SELECTIVE ANTIBACTERIAL ACTIVITY OF THE CATIONIC PEPTIDES PaDBS1R6 AGAINST GRAM-NEGATIVE BACTERIA
Isabel C. M. Fensterseifer, Mario R. Felicio, Eliane S. F. Alves, Marlon H. Cardoso, Marcelo Der Torossian Torres, Carolina O. Matos, Osmar N. Silva, Timothy K. Lu, Mauricio V. Freire, Natan C. Neves, Sonia Gonçalves, Luciano M. Liao, Nuno C. Santos, William F. Porto, Cesar de la Fuente-Nunez*, Octavio L. Franco
Biochimica et Biophysica Acta (BBA) - Biomembranes,  2019, 1861 (7), 1375-1387

 

PEPTIDE DESIGN PRINCIPLES FOR ANTIMICROBIAL APPLICATIONS
Marcelo Der Torossian Torres, Shanmugapriya Sothiselvam, Timothy K. Lu, and Cesar de la Fuente-Nunez*
Journal of Molecular Biology, 2019

 

2018

STRUCTURE-FUNCTION-GUIDED EXPLORATION OF THE ANTIMICROBIAL PEPTIDE POLYBIA-CP IDENTIFIES ACTIVITY DETERMINANTS AND GENERATES SYNTHETIC THERAPEUTICS CANDIDATES
Marcelo Der Torossian Torres, Cibele N. Pedron, Yasutomi Higashikuni, Robin M. Kramer, Marlon H. Cardoso, Karen G. N. Oshiro, Octávio L. Franco, Pedro I. Silva Junior, Fernanda D. Silva, Vani X. Oliveira Junior, Timothy K. Lu, Cesar de la Fuente-Nunez*
Nature Communications Biology, 2018, 1, 221 (Editor's pick)

 

IDENTIFICATION OF NOVEL CRYPTIC MULTIFUNCTIONAL ANTIMICROBIAL PEPTIDES FROM THE HUMAN STOMACH ENABLED BY A COMPUTATIONAL–EXPERIMENTAL PLATFORM
Katia Pane, Valeria Cafaro, Angela Avitable, Marcelo Der Torossian Torres, Adriana Vollaro, Eliana De Gregorio, Maria Rosaria Catania, Antimo Di Maro, Andrea Bosso, Giovanni Gallo, Anna Zanfardino, Mario Varcamonti, Elio Pizzo, Alberto Di Donato, Thimothy K. Lu, Cesar de la Fuente-Nunez*, and Eugenio Notomista
ACS Synthetic Biology, 2018, 7 (9), 2105–2115

 

NOVEL BIOACTIVE PEPTIDES FROM PD-L1/2, A TYPE 1 RIBOSOME INACTIVATING PROTEIN FROM PHYTOLACCA DIOICA L. EVALUATION OF THEIR ANTIMICROBIAL PROPERTIES AND ANTI-BIOFILM ACTIVITIES
Elio Pizzo, Katia Pane, Andrea Bosso, Nicola Landi, Sara Ragucci, Rosita Russo, Rosa Gaglione, Marcelo Der Torossian Torres, Cesar de la Fuente-Nunez, Angela Arciello, Alberto Di Donato, Eugenio Notomista, Antimo Di Maro
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2018, 1860 (7), 1425-1435
PEPTIDE DESIGN ENABLES REENGINEERING OF AN INACTIVE WASP VENOM PEPTIDE INTO SYTHETIC ANTIPLASMODIAL AGENTS
Marcelo Der Torossian Torres, Adriana Farias Silva, Cibele Nicolaski Pedron, Margareth Lara Capurro, Cesar de la Fuente‐Nunez*, and Vani Xavier Oliveira Junior
ChemistrySelect, 2018, 3 (21), 5859-5863
NATURAL AND REDESIGNED WASP VENOM PEPTIDES WITH SELECTIVE ANTITUMORAL ACTIVITY
Marcelo Der Torossian Torres, Gislaine Patricia Andrade, Roseli Hiromi Sato, Cibele Nicolaski Pedron, Tania Maria Manieri, Giselle Cerchiaro, Anderson Orzari Ribeiro, Cesar de la Fuente‐Nunez*, and Vani Xavier Oliveira Junior
Beilstein Journal of Organic Chemistry, 2018, 14, 1693–1703
IN SILICO OPTIMIZATION OF A GUAVA ANTIMICROBIAL PEPTIDE ENABLES COMBINATORIAL EXPLORATION FOR PEPTIDE DESIGN 
William F. Porto, Luz Irazazabal, Eliane S. F. Alves, Suzana M. Ribeiro, Carolina O. Matos, Állan S. Pires, Isabel C. M. Fensterseifer, Vivian J. Miranda, Evan F. Haney, Vincent Humblot, Marcelo D. T. Torres, Robert E. W. Hancock, Luciano M. Liao, Ali Ladram, Timothy K. Lu, Cesar de la Fuente-Nunez*, and Octavio L. Franco
Nature Communications, 2018, 9, 1490
DEVELOPMENT OF MOLECULARLY IMPRINTED POLYMERS TO BLOCK QUORUM SENSING AND INHIBIT BACTERIAL BIOFILM FORMATION
Luyao Ma, Shaolong Feng, César de la Fuente-Núñez, Robert E. W. Hancock, and Xiaonan Lu
ACS Applied Materials and Interfaces, 2018, 10 (22), 18450–18457
VERSATILE AND ON-DEMAND BIOLOGICS CO-PRODUCTION IN YEAST
Jicong Cao, Pablo Perez-Pinera, Ky Lowenhaupt, Ming-Ru Wu, Oliver Purcell, Cesar de la Fuente-Nunez, and Timothy K. Lu
Nature Communications, 2018, 9, 77
YEAST-BASED SYNTHETIC BIOLOGY PLATFORM FOR ANTIMICROBIAL PEPTIDE PRODUCTION
Jicong Cao, Cesar de la Fuente-Nunez, Rui Wen Ou, Marcelo Der Torossian Torres, Santosh G. Pande, Anthony J. Sinskey, and Timothy K. Lu
ACS Synthetic Biology, 2018, 7 (3), 896–902
MAGNETIC SURFACTANT IONIC LIQUIDS AND POLYMERS WITH TETRAHALOFERRATE (III) ANIONS AS ANTIMICROBIAL AGENTS WITH LOW CYTOTOXICITY
Cesar de la Fuente-Nunez, Paul Brown, Marcelo Der Torossian Torres, Jicong Cao, and Timothy K. Lu
Colloid and Interface Science Communications, 2018, 22, 11-13

2017

3D PRINTING OF LIVING RESPONSIVE MATERIALS AND DEVICES
Xinyue Liu, Hyunwoo Yuk, Shaoting Lin, German Alberto, Parada Tzu‐Chieh Tang, Eléonore Tham, Cesar de la Fuente‐Nunez, Timothy K. Lu, and Xuanhe Zhao
Advanced Materials, 2017, 1704821
NEUROMICROBIOLOGY: HOW MICROBES INFLUENCE THE BRAIN
Cesar de la Fuente-Nunez, Beatriz Torres Meneguetti, Octávio Luiz Franco, and Timothy K. Lu
ACS Chemical Neuroscience, 2018, 9 (2), 141–150
ANTIMICROBIAL PEPTIDES: ROLE IN HUMAN DISEASE AND POTENTIAL AS IMMUNOTHERAPIES
César de la Fuente-Núñez, Osmar N. Silva, Timothy K. Lu, and Octavio Luiz Franco
Pharmacology and Therapeutics, 2017, 178, 132-140
CIPROFLOXACIN-NITROXIDE HYBRIDS WITH POTENTIAL FOR BIOFILMS CONTROL
Anthony D. Verderosa, César de la Fuente-Núñez, Sarah C. Mansour, Jicong Cao, Timothy K. Lu, Robert E. W. Hancock, and Kathryn E. Fairfull-Smith
European Journal of Medicinal Chemistry, 2017, 138, 590-601
CO2-REACTIVE IONIC LIQUID SURFACTANTS FOR THE CONTROL OF COLLOIDAL MORPHOLOGY
Paul Brown, Vishnu Sresht, Burak H. Eral, Andrew Fiore, César de la Fuente-Núñez, Marcus O’Mahony, Gabriel P. Mendes, William T. Heller, Patrick S. Doyle, Daniel Blankschtein, and T. Alan Hatton
Langmuir, 2017, 33 (31), 7633–7641
NEXT-GENERATION PRECISION ANTIMICROBIALS: TOWARDS PERSONALIZED TREATMENT OF INFECTIOUS DISEASES
Cesar de la Fuente-Nunez, Marcelo D. T. Torres, Francisco J. M. Mojica, and Timothy K. Lu
Current Opinion in Microbiology, 2017, 37, 95-102
AN IMMUNOMODULATORY PEPTIDE THAT CONFERS PROTECTION IN AN EXPERIMENTAL CANDIDEMIA MURINE MODEL
Camila G. Freitas, Stella M. F. Lima, Mirna S. Freire, Ana Paula C. Cantuária, Nelson G. O. Júnior, Tatiane S. Santos, Jéssica S. Folha, Suzana M. Ribeiro, Simoni C. Dias, Taia M. B. Rezende, Patrícia Albuquerque, André M. Nicola, César de la Fuente-Núñez, Robert E. W. Hancock, Octávio L. Franco, Maria Sueli S. Felipe
Antimicrobial Agents and Chemotherapy, 2017, AAC.02518-16
ANTIMICROBIAL EFFICACY AGAINST PSEUDOMONAS AERUGINOSA BIOFILM FORMATION IN A THREE-DIMENSIONAL LUNG EPITHELIAL MODEL AND THE INFLUENCE OF FETAL BOVINE SERUM
Aurélie Crabbé, Yulong Liu, Nele Matthijs, Petra Rigole, César De La Fuente-Nùñez, Richard Davis, Maria A. Ledesma, Shameema Sarker, Rob Van Houdt, Robert E. W. Hancock, Tom Coenye, and Cheryl A. Nickerson
Scientific Reports, 2017, 7, 43321
THE NEXT GENERATION OF ANTIMICROBIAL PEPTIDES (AMPS)AS MOLECULAR THERAPEUTIC TOOLS FOR THE TREATMENT OF DISEASES WITH SOCIAL AND ECONOMIC IMPACTS
Nicolau B. da Cunha, Nicole B. Cobacho, Juliane F. C. Viana, Loiane A. Lima, Kamila B. O. Sampaio, Stephan S. M. Dohms, Arthur C. R. Ferreira, César de la Fuente-Núñez, Fabrício F. Costa, Octávio L. Franco, and Simoni C. Dias
Drug Discovery Today, 2017, 22 (2), 234-248
CHARACTERIZATION OF MULTI-DRUG RESISTANT ENTEROCOCCUS FAECALIS ISOLATED FROM CEPHALIC RECORDING CHAMBERS IN RESEARCH MACAQUES (MACACA SPP.)
Stephanie E. Woods, Mia T. Lieberman, Francois Lebreton, Elise Trowel, César de la Fuente-Núñez, Joanne Dzink-Fox, Michael S. Gilmore, and James G. Fox
PLOS ONE, 2017, 12(1):e0169293